Please use this identifier to cite or link to this item: https://doi.org/10.1016/0006-291X(92)90470-6
DC FieldValue
dc.titleAdenosine modulates cell growth in human epidermoid carcinoma (A431) cells
dc.contributor.authorTey, H.B.
dc.contributor.authorKhoo, H.E.
dc.contributor.authorTan, C.H.
dc.date.accessioned2013-06-05T09:48:44Z
dc.date.available2013-06-05T09:48:44Z
dc.date.issued1992
dc.identifier.citationTey, H.B., Khoo, H.E., Tan, C.H. (1992). Adenosine modulates cell growth in human epidermoid carcinoma (A431) cells. Biochemical and Biophysical Research Communications 187 (3) : 1486-1492. ScholarBank@NUS Repository. https://doi.org/10.1016/0006-291X(92)90470-6
dc.identifier.issn0006291X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/38233
dc.description.abstractAdenosine mediates many physiological functions via activation of extracellular receptors. The modulation of cell growth by adenosine was found to be receptor-mediated. In A431 cells adenosine evoked a biphasic response in which a low concentration (~10 μM) produced inhibition of colony formation but at higher concentrations (up to 100 μM) this inhibition was progressively reversed. Evidence for the involvement of A1 (inhibitory) and A2 (stimulatory) adenosine receptors in regulating cell growth of these tumor cells was obtained through plating efficiency studies based on the relative potency of adenosine agonists and antagonists. When both A1 and A2 receptors were blocked, colony formation or growth was not inhibited at low concentrations of adenosine but was inhibited at high adenosine concentrations.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0006-291X(92)90470-6
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/0006-291X(92)90470-6
dc.description.sourcetitleBiochemical and Biophysical Research Communications
dc.description.volume187
dc.description.issue3
dc.description.page1486-1492
dc.description.codenBBRCA
dc.identifier.isiutA1992JQ81200040
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