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Title: Snake postsynaptic neurotoxins: Gene structure, phylogeny and applications in research and therapy
Authors: Yee, J.S.P.
Nanling, G.
Afifiyan, F.
Donghui, M.
Lay, P.S.
Armugam, A. 
Jeyaseelan, K. 
Keywords: Drug discovery
Evolutionary origin
Snake venom
Issue Date: 2004
Citation: Yee, J.S.P., Nanling, G., Afifiyan, F., Donghui, M., Lay, P.S., Armugam, A., Jeyaseelan, K. (2004). Snake postsynaptic neurotoxins: Gene structure, phylogeny and applications in research and therapy. Biochimie 86 (2) : 137-149. ScholarBank@NUS Repository.
Abstract: Snake venoms are complex mixtures of biologically active polypeptides that target a variety of vital physiological functions in mammals. α-Neurotoxins, toxins that cause paralysis by binding to the nicotinic receptors at the postsynaptic region of the neuromuscular junction have been widely studied in terms of their structure-function relationships as well as gene structure, organization and expression. In this review, we describe the structure of α-neurotoxin genes and discuss their evolutionary relationships. Almost all members of neurotoxins have been found to exhibit a common evolutionary origin. The importance of α-neurotoxins in therapy and research has also been discussed to highlight their potential applications especially in the area of drug discovery. © 2003 Elsevier SAS. All rights reserved.
Source Title: Biochimie
ISSN: 03009084
DOI: 10.1016/j.biochi.2003.11.012
Appears in Collections:Staff Publications

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