Please use this identifier to cite or link to this item:
Title: Snake postsynaptic neurotoxins: Gene structure, phylogeny and applications in research and therapy
Authors: Yee, J.S.P.
Nanling, G.
Afifiyan, F.
Donghui, M.
Lay, P.S.
Armugam, A. 
Jeyaseelan, K. 
Keywords: Drug discovery
Evolutionary origin
Snake venom
Issue Date: 2004
Citation: Yee, J.S.P., Nanling, G., Afifiyan, F., Donghui, M., Lay, P.S., Armugam, A., Jeyaseelan, K. (2004). Snake postsynaptic neurotoxins: Gene structure, phylogeny and applications in research and therapy. Biochimie 86 (2) : 137-149. ScholarBank@NUS Repository.
Abstract: Snake venoms are complex mixtures of biologically active polypeptides that target a variety of vital physiological functions in mammals. α-Neurotoxins, toxins that cause paralysis by binding to the nicotinic receptors at the postsynaptic region of the neuromuscular junction have been widely studied in terms of their structure-function relationships as well as gene structure, organization and expression. In this review, we describe the structure of α-neurotoxin genes and discuss their evolutionary relationships. Almost all members of neurotoxins have been found to exhibit a common evolutionary origin. The importance of α-neurotoxins in therapy and research has also been discussed to highlight their potential applications especially in the area of drug discovery. © 2003 Elsevier SAS. All rights reserved.
Source Title: Biochimie
ISSN: 03009084
DOI: 10.1016/j.biochi.2003.11.012
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Nov 13, 2019


checked on Nov 13, 2019

Page view(s)

checked on Oct 28, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.