Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(03)01039-1
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dc.titleStructurally conserved α-neurotoxin genes encode functionally diverse proteins in the venom of Naja sputatrix
dc.contributor.authorJeyaseelan, K.
dc.contributor.authorPoh, S.L.
dc.contributor.authorNair, R.
dc.contributor.authorArmugam, A.
dc.date.accessioned2013-06-05T09:47:15Z
dc.date.available2013-06-05T09:47:15Z
dc.date.issued2003
dc.identifier.citationJeyaseelan, K., Poh, S.L., Nair, R., Armugam, A. (2003). Structurally conserved α-neurotoxin genes encode functionally diverse proteins in the venom of Naja sputatrix. FEBS Letters 553 (3) : 333-341. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(03)01039-1
dc.identifier.issn00145793
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/38165
dc.description.abstractThe structure and organization of the genes encoding the long-chain neurotoxins and four other isoforms of weak neurotoxins in the venom of Naja sputatrix are reported. The genes contained three exons interrupted by two introns, a structure similar to other members of the three-finger toxin family. The proteins encoded by these genes, however, show varied affinity towards nicotinic acetylcholine receptors. Phylogenetic analysis of these genes showed that the weak neurotoxin gene is confined to a distinct group. We also observe that specific mutations of the gene provide the diversity in function in these toxins while maintaining a common structural scaffold. This forms the first report where the molecular basis of evolution of postsynaptic neurotoxins from an ancestral gene can be demonstrated using the same species of snake. © 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-5793(03)01039-1
dc.sourceScopus
dc.subjectα-Neurotoxin
dc.subjectAccelerated evolution
dc.subjectCo-evolution
dc.subjectNaja sputatrix
dc.subjectNicotinic acetylcholine receptor
dc.subjectWeak neurotoxin
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/S0014-5793(03)01039-1
dc.description.sourcetitleFEBS Letters
dc.description.volume553
dc.description.issue3
dc.description.page333-341
dc.description.codenFEBLA
dc.identifier.isiut000186134300019
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