Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0014-5793(01)02912-X
DC Field | Value | |
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dc.title | Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts | |
dc.contributor.author | Liang, F. | |
dc.contributor.author | Chang, C.F. | |
dc.date.accessioned | 2013-06-05T09:45:50Z | |
dc.date.available | 2013-06-05T09:45:50Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Liang, F., Chang, C.F. (2001). Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts. FEBS Letters 506 (3) : 207-210. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(01)02912-X | |
dc.identifier.issn | 00145793 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/38098 | |
dc.description.abstract | CD157, a glycosylphosphatidylinositol-anchored protein, has previously been shown to mediate tyrosine phosphorylation of a 130 kDa protein (p130) in several cell lines. In this study, we have identified the p130 protein to be focal adhesion kinase (FAK or pp125FAK). FAK undergoes phosphorylation at Tyr-397 and Tyr-861 in intact MCA102 cells stably transfected with CD157 (MCA/CD157). MCA/CD157 cells, which displayed a rounded and compact cell morphology, exhibited a dispersed distribution, in contrast to a more closely associated and elongated spindle cell shape in the vector-transfected cells. MCA/CD157 cells proliferated at a rate 20-25% slower than the control cells. Our results demonstrate, for the first time, that FAK is a downstream signalling molecule of CD157. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-5793(01)02912-X | |
dc.source | Scopus | |
dc.subject | CD157 | |
dc.subject | Focal adhesion kinase | |
dc.subject | Localization | |
dc.subject | Morphology | |
dc.subject | Proliferation | |
dc.subject | Tyrosine phosphorylation | |
dc.type | Article | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1016/S0014-5793(01)02912-X | |
dc.description.sourcetitle | FEBS Letters | |
dc.description.volume | 506 | |
dc.description.issue | 3 | |
dc.description.page | 207-210 | |
dc.description.coden | FEBLA | |
dc.identifier.isiut | 000171688200008 | |
Appears in Collections: | Staff Publications |
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