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Title: Investigating neurotrophic factors that regulate axonal regeneration in muscle lacerations
Keywords: intra-muscular nerve damage, lacerated skeletal muscles, neurotrophic factors, muscle atrophy, axonal regeneration, muscle fibrosis
Issue Date: 14-Aug-2012
Citation: HAN HWAN CHOUR (2012-08-14). Investigating neurotrophic factors that regulate axonal regeneration in muscle lacerations. ScholarBank@NUS Repository.
Abstract: The functional recovery of lacerated skeletal muscles is slow and incomplete, dependent on the integrity of the intra-muscular nerve. This study investigates gene and protein expression profiles of neurotrophic factors, atrophic factors and fibrosis factors during the early (2-weeks) and late phase (12-weeks) of repair using the medial gastrocnemius of adult male Sprague-Dawley rats. It is hypothesized that specific endogenous anti-fibrosis, anti-atrophic and pro-muscle re-innervation factors improve muscle and axonal regeneration in the early phase post-laceration. The mRNA and protein expression levels of targets in lacerated muscle models involving three different intramuscular nerve injuries were studied. In lacerated skeletal muscles with the intra-muscular nerve preserved intact, high expression levels of NT4, GDNF, CNTF, EGF, IGF1, HGF and Galectin-1 significantly enhanced the muscle regeneration via reduction in fibrosis and atrophy over 12-weeks post-laceration. This offers a rationale for targeting these factors to improve the recovery of lacerated skeletal muscles.
Appears in Collections:Master's Theses (Open)

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