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|Title:||Responses of polycystic ovarian syndrome and related variants to low-dose follicle stimulating hormone||Authors:||Yong, E.L.
|Keywords:||Chronic low-dose FSH
Polycystic ovarian syndrome
Polycystic ovarian syndrome-like
|Issue Date:||1997||Citation:||Yong, E.L., Ng, S.C., Chan, C., Kumar, J., Teo, L.S., Ratnam, S. (1997). Responses of polycystic ovarian syndrome and related variants to low-dose follicle stimulating hormone. International Journal of Gynecology and Obstetrics 57 (3) : 305-311. ScholarBank@NUS Repository.||Abstract:||Objective: To determine whether patients with classical polycystic ovarian syndrome (PCOS) respond differently to low-dose FSH therapy in comparison with anovulatory patients (PCOS-like) where only some features of PCOS are present. Methods: Two groups of patients were studied. The PCOS group (25 patients, 51 cycles) and the PCOS-like group (38 patients, 57 cycles) were treated with the same protocol of purified FSH, commencing with an initial dosage of 75 IU/day and increasing by 37.5 IU/day after 14 days, where necessary. Estradiol levels and ultrasonographic evidence of follicular development were used for monitoring. Results: PCOS patients required more ampules of FSH, needed more days of gonadotropin stimulation, secreted higher levels of E2 and had increased numbers of intermediate follicles compared to the PCOS-like group. Conclusions: This study demonstrated significant differences between PCOS and other PCOS-like conditions when treated with low-dose FSH. Classification of the subvariants of PCOS may have therapeutic implications.||Source Title:||International Journal of Gynecology and Obstetrics||URI:||http://scholarbank.nus.edu.sg/handle/10635/37171||ISSN:||00207292|
|Appears in Collections:||Staff Publications|
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