Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0168-8227(99)00138-2
DC FieldValue
dc.titleMitochondrial gene mutations in gestational diabetes mellitus
dc.contributor.authorChen, Y.
dc.contributor.authorLiao, W.X.
dc.contributor.authorRoy, A.C.
dc.contributor.authorLoganath, A.
dc.contributor.authorNg, S.C.
dc.date.accessioned2013-04-10T02:59:18Z
dc.date.available2013-04-10T02:59:18Z
dc.date.issued2000
dc.identifier.citationChen, Y., Liao, W.X., Roy, A.C., Loganath, A., Ng, S.C. (2000). Mitochondrial gene mutations in gestational diabetes mellitus. Diabetes Research and Clinical Practice 48 (1) : 29-35. ScholarBank@NUS Repository. https://doi.org/10.1016/S0168-8227(99)00138-2
dc.identifier.issn01688227
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/36947
dc.description.abstractMitochondrial DNA mutations have been implicated in many diseases including diabetes mellitus. Although gestational diabetes mellitus (GDM) has been suggested to have genetic determinant and to be etiologically indistinct with non-insulin-dependent diabetes mellitus (NIDDM), its association with mitochondrial gene mutations is still unknown. In this study, 137 patients with GDM and 292 non-diabetic pregnant controls were examined for mitochondrial DNA mutations from the nucleotide 3130-4260 encompassing tRNA- Leu gene and adjacent NADH dehydrogenase 1 gene by polymerase chain reaction, single-stranded conformation polymorphism, restriction fragment length polymorphism and DNA sequencing. One heteroplasmic mutation at the position of 3398 (T-C), which changed a highly conserved methionine to threonine in NADH dehydrogenase subunit 1, was identified in 2.9% GDM patients but not in the controls, indicating its association with GDM (P = 0.01). Two novel mutations, a heteroplasmic C3254A and a homoplasmic A3399T, were also found in GDM subjects, the functional meaning of which merits further investigation. G3316A and T3394C mutations implicated in NIDDM, were seen at higher frequencies in patients with GDM than the controls. Our results suggest that mitochondrial DNA mutations may contribute to the development of GDM in some patients. (C) 2000 Elsevier Science Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0168-8227(99)00138-2
dc.sourceScopus
dc.subjectGDM
dc.subjectMitochondrial DNA
dc.subjectMutations
dc.subjectND1 gene
dc.subjecttRNA-Leu
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/S0168-8227(99)00138-2
dc.description.sourcetitleDiabetes Research and Clinical Practice
dc.description.volume48
dc.description.issue1
dc.description.page29-35
dc.description.codenDRCPE
dc.identifier.isiut000086006000005
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