Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0015-0282(00)01616-2
DC FieldValue
dc.titleAssociation of AccI polymorphism in the follicle-stimulating hormone β gene with polycystic ovary syndrome
dc.contributor.authorTong, Y.
dc.contributor.authorLiao, W.-X.
dc.contributor.authorRoy, A.C.
dc.contributor.authorNg, S.C.
dc.date.accessioned2013-04-10T02:59:02Z
dc.date.available2013-04-10T02:59:02Z
dc.date.issued2000
dc.identifier.citationTong, Y., Liao, W.-X., Roy, A.C., Ng, S.C. (2000). Association of AccI polymorphism in the follicle-stimulating hormone β gene with polycystic ovary syndrome. Fertility and Sterility 74 (6) : 1233-1236. ScholarBank@NUS Repository. https://doi.org/10.1016/S0015-0282(00)01616-2
dc.identifier.issn00150282
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/36931
dc.description.abstractObjective: To search for FSH β-subunit gene mutations in patients with polycystic ovary syndrome (PCOS) and determine the association between the mutations and the syndrome. Design: Clinical and molecular studies. Setting: Clinics and laboratories of the National University Hospital Obstetrics and Gynecology Department in Singapore. Patient(s): One hundred thirty-five patients with PCOS and 105 normal control subjects. Intervention(s): Exons two and three were screened for mutations by single-stranded conformational polymorphism and DNA sequencing. Main Outcome Measure(s): Polymerase chain reaction followed by restriction enzyme analysis. Result(s): No missense mutation was found in the functional units of the FSHβ gene in patients with PCOS, but a thymine-cytosine substitution in exon 3 (codon 76, TAT to TAC) was identified. The nucleotide change led to creation of an AccI digestion site. The distribution pattern of AccI polymorphism in the patients was significantly different from that in the control group, and the occurrence of homozygous carriers was significantly higher in patients (12.6%) than in the control group (3.8%). The frequency of polymorphism and prevalence of homozygosity were significantly higher in patients with PCOS with obesity (0.50% and 31.0%, respectively) than in those with menstrual disorders only (0.366% and 8.5%, respectively), which correlated with significantly higher androgen levels in the obese patients. Conclusion(s): The AccI polymorphism in FSHβ gene may be associated with PCOS in some women, especially those with obesity. Copyright (C) 2000 American Society for Reproductive Medicine.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0015-0282(00)01616-2
dc.sourceScopus
dc.subjectFollicle-stimulating hormone β gene
dc.subjectObesity
dc.subjectPolycystic ovary syndrome
dc.subjectPolymorphism
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/S0015-0282(00)01616-2
dc.description.sourcetitleFertility and Sterility
dc.description.volume74
dc.description.issue6
dc.description.page1233-1236
dc.description.codenFESTA
dc.identifier.isiut000165897300030
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

31
checked on Dec 8, 2021

WEB OF SCIENCETM
Citations

22
checked on Dec 8, 2021

Page view(s)

199
checked on Dec 2, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.