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Title: The efficacy of two dosages of a continuous combined hormone replacement regimen
Authors: Loh, F.H. 
Chen, L.H.
Yu, S.L.
Jorgensen, L.N.
Keywords: Bleeding patterns
Bone markers
Hormone replacement therapy
Postmenopausal women
Issue Date: 2002
Citation: Loh, F.H., Chen, L.H., Yu, S.L., Jorgensen, L.N. (2002). The efficacy of two dosages of a continuous combined hormone replacement regimen. Maturitas 41 (2) : 123-131. ScholarBank@NUS Repository.
Abstract: Objectives: To evaluate the efficacy of a low-dose combination of estradiol (E2) and norethisterone acetate (NETA) on bone markers, lipid and bleeding profiles and menopausal symptoms. Method: Ninety-six healthy Chinese postmenopausal women were allocated randomly to receive 1 mg E2/0.5 mg NETA (low-dose hormone replacement therapy (HRT)) or 2 mg E2/1 mg NETA (high-dose HRT) for 6 months. Results: Bone resorption markers (collagen I N-terminal telopeptides (NTX) and deoxypyridinoline (dPyr)) were significantly reduced; -66 and -32%, respectively, in high-dose HRT versus -55 and -24%, respectively, in low-dose HRT. Bone-specific alkaline phosphatase remained unchanged with either combination of hormones. Total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels were decreased significantly (-12 and -13%, respectively, in high-dose HRT vs. -7 and -8% in low-dose HRT). High density lipoprotein cholesterol (HDL-C) was decreased to a lesser extent in low-dose HRT and triglycerides (TG) levels remained unchanged. Both the low and high-dose HRT were effective in alleviating menopausal symptoms. After 6 months of treatment, 2% of women in the low-dose HRT were bleeding compared with 23% in the high-dose HRT. Breast pain occurred in 2% of women in low-dose HRT compared with 15% in high-dose HRT. The endometrium in the majority of the women remained normal. Conclusion: Menopausal symptoms were reduced effectively in postmenopausal women on either low-dose or high-dose HRT. TC, LDL-C levels and bone resorption markers were reduced in a dose-dependent manner. Low-dose HRT provided a better bleeding profile and the incidence of breast pain was low. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Source Title: Maturitas
ISSN: 03785122
DOI: 10.1016/S0378-5122(01)00276-6
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