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Title: Ovarian hyperstimulation syndrome is associated with reversible impairment of vascular reactivity
Authors: Foong, L.-C. 
Bhagavath, B.
Kumar, J. 
Ng, S.-C. 
Keywords: Ovarian hyperstimulation syndrome (OHSS)
Vascular reactivity
Issue Date: 2002
Citation: Foong, L.-C., Bhagavath, B., Kumar, J., Ng, S.-C. (2002). Ovarian hyperstimulation syndrome is associated with reversible impairment of vascular reactivity. Fertility and Sterility 78 (6) : 1159-1163. ScholarBank@NUS Repository.
Abstract: Objective: To determine if there is a loss of normal peripheral arteriolar vasoconstrictor reactivity in women with severe ovarian hyperstimulation syndrome (OHSS). Design: Prospective controlled study. Setting: National University Hospital, Singapore. Patient(s): Forty-three women undergoing treatment in an IVF program: 22 women with severe OHSS and 21 normal women without OHSS. Intervention(s): Measurement and quantification of the cutaneous arteriolar vasoconstrictor response using laser Doppler fluximetry. Main Outcome Measure(s): Changes in blood flow as an index of vasoconstrictor response before and after treatment for OHSS with albumin. Result(s): The mean (±SE) percentage (%) change in normal control women was -68.3% ± 4.7. This was significantly different from women with OHSS (-32.3% ± 11.1). The response in women with OHSS changed significantly after treatment with IV albumin (-60.4% ± 5.7) and was no different than the control response. The reproducibility of the technique was -13.6% (±2.8). Conclusion(s): Women with OHSS have impaired vascular reactivity when compared with normal women. © 2002 by American Society for Reproductive Medicine.
Source Title: Fertility and Sterility
ISSN: 00150282
DOI: 10.1016/S0015-0282(02)04392-3
Appears in Collections:Staff Publications

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