Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/35477
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dc.titleHEMANGIOBLAST PROGENITOR CELLS
dc.contributorNATIONAL UNIVERSITY OF SINGAPORE
dc.contributorAGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
dc.contributor.authorLIM, SAI KING
dc.date.accessioned2012-11-21T08:58:25Z
dc.date.available2012-11-21T08:58:25Z
dc.date.issued2004-01-22
dc.identifier.citationLIM, SAI KING (2004-01-22). HEMANGIOBLAST PROGENITOR CELLS. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/35477
dc.description.abstractThe invention relates to isolated hemangioblast cells. Hematopoietic and endothelial cells are postulated to be derived from a common progenitor, hemangioblast. While hemangioblast has been isolated retrospectively during embryonic stem cell differentiation, it has not been isolated from embryos or from bone marrow. Prospectively stable clonal cell lines have been isolated from mammalian embryos, from embryonic stem cells and from mammalian bone marrow that can differentiate in vitro into tubular structures with both endothelial and hematopoietic markers such as CD34, CD31, Flk-1, TIE2, P-selectin, Sca-1, thy-1, CD45, and smooth muscle actin. Gene expression profiles in the undifferentiated and differentiated cells were consistent with endothelial and hematopoietic differentiation potential. Transplantation studies in isogenic or immunodeficient mice demonstrated that these cells were not tumorigenic. In an appropriate microenvironment, the cells incorporate into the vasculature and participate in hematopoiesis.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/http://analytics.patsnap.com/patent_view/view?pn=WO2004007698A1
dc.sourcePatSnap
dc.typePatent
dc.contributor.departmentBIOCHEMISTRY
dc.identifier.isiutNOT_IN_WOS
dc.description.patentnoWO2004007698A1
dc.description.patenttypePublished Application
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