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Title: Synthesis of superparamagnetic nanostructures and their magnetic resonance imaging applications
Keywords: Superparamagnetic, nanoparticles, MRI, biomedical, magnetite, copolymer
Issue Date: 30-Mar-2012
Citation: CHOO SHI GUANG, EUGENE (2012-03-30). Synthesis of superparamagnetic nanostructures and their magnetic resonance imaging applications. ScholarBank@NUS Repository.
Abstract: In this thesis, the fabrication of spherical superparamagnetic composite nanostructures was proposed. The objective was to study the magnetic behaviour of such nanostructures based on supermagnetic nanocrystal (SPMN) assemblies within a polymeric matrix. The application was aimed at improving current superparamagnetic contrast agents utilized in magnetic resonance imaging (MRI). Hence, much work was focused on investigating and exploiting unique behaviours of SPMNs for enhancing MRI contrast effects. By varying the packing density of SPMNs within a sphere, the separation distance between the nanocrystals was readily controlled. Thus, deeper insight could be gained regarding magnetic interaction behaviors between SPMNs by varying the particle separation. The particles were broadly characterized in terms of size, morphology, composition, magnetic properties, pH/colloidal stability, and cytotoxicity. The magnetic nanocomposites were found to greatly enhance T2*-weighted MRI, and also produce a discrete frequency shift in water protons that have potential for MR spectroscopic imaging.
Appears in Collections:Ph.D Theses (Open)

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