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Title: Functional Cellulose Derivatives and Their Applications in Food and Pharmaceutical Products
Keywords: non aquoeus system, gel, rheology, drug delivery, ethyl cellulose, propylene glycol dicaprylate
Issue Date: 30-Sep-2011
Citation: LILIA BRUNO (2011-09-30). Functional Cellulose Derivatives and Their Applications in Food and Pharmaceutical Products. ScholarBank@NUS Repository.
Abstract: The availability of a substantial number of topically useful but moisture sensitive drugs in the market calls for more research in the formulation and in depth study of suitable non aqueous vehicles that can ensure drug stability. Compared to hydrogels, the solvent toxicity issues related to non aqueous systems have limited their use in the drug transdermal and topical delivery. However, there have been a couple of non aqueous systems developed which have been able to transcend these issues. In this thesis, we explore the structural properties of one such system comprising of ethyl cellulose and a non aqueous solvent, propylene glycol dicaprylate. The structural changes with respect to temperature and time were explored to throw light on the gelation mechanism of the system. These studies were also extended to include the effect of polymer molecular weight on the properties and gelation of the system. Further , we also studied the effect of moisture on these systems and its distribution within the gel network was found to be of great interest and critical to its application.
Appears in Collections:Ph.D Theses (Open)

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