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Title: Regulation of substance P and Neurokinin-1 receptor expression in a mouse model of acute pancreatitis
Keywords: acute pancreatitis, caerulein, substance P, neurokinin-1 receptor, neutral endopeptidase, mouse
Issue Date: 2-Mar-2012
Citation: KOH YUNG HUA (2012-03-02). Regulation of substance P and Neurokinin-1 receptor expression in a mouse model of acute pancreatitis. ScholarBank@NUS Repository.
Abstract: Substance P (SP)-neurokinin-1 receptor (NK1R) interaction has been identified as a key mediator of experimental acute pancreatitis (AP) but mechanisms that regulate their expression were not clear. In this thesis, we described three possible mechanisms that regulate SP/NK1R expression in a murine model of caerulein-induced AP. Firstly, caerulein could directly stimulate CCKA receptors, and caused up-regulation via a PKC-MAPK-NF-kB dependant mechanism. Secondly, activation of NK1R itself could cause up-regulation of SP/NK1R, possibly via similar downstream mechanisms with caerulein. Lastly, caerulein might also cause inhibition and down-regulation of neutral endopeptidase (NEP) activity. A diminished NEP activity will then increase SP bioavailability and thus potentiates SP-NK1R interaction and subsequent inflammation.
Appears in Collections:Ph.D Theses (Open)

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