Please use this identifier to cite or link to this item:
Title: Antigen-specific Effector CD8 T Cells Regulate Allergic Responses via IFN-y and Dendritic Cell Function
Keywords: antigen-specific, CD8 T cells, dendritic cells, IFN-gamma, asthma, mouse
Issue Date: 19-Jan-2012
Citation: TANG YAFANG (2012-01-19). Antigen-specific Effector CD8 T Cells Regulate Allergic Responses via IFN-y and Dendritic Cell Function. ScholarBank@NUS Repository.
Abstract: In this study, we aim to investigate the potential of CD8 T cells to modulate the elicitation of allergic inflammation and investigate the underlying mechanisms. Effector CD8 T cells from OT-I and IFN-gamma-/-OT-I mice were transferred to OVA-sensitized mice one day before OVA challenges. The effect on lung dendritic cells (DCs) exerted by CD8 T cells was studied with ex vivo culture of sorted DCs from treatment mice with either naive or antigen-experienced CD4 T cells. We found that effector OT-I, but not IFN-gamma-/-OT-I CD8 T cells attenuated eosinophilia and mucus secretion in the lungs of sensitized mice in an antigen-specific manner. Effector IFN-gamma-/-OT-I CD8 T cells displayed a Tc2/Tc17-biased phenotype with weaker cytotoxicity and were able to both induce and exacerbate eosinophilia as well as neutrophilia. OT-I CD8 T cells increased the ability of lung CD11b+CD103- DCs to both prime the differentiation of naive CD4 T cells toward a Th1 phenotype and enhance IFN-gamma production by antigen-experienced lung CD4 T cells.
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
TangYF.pdf.pdf5.51 MBAdobe PDF



Page view(s)

checked on Dec 1, 2020


checked on Dec 1, 2020

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.