Please use this identifier to cite or link to this item:
Title: Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: A nuclear microscopic study
Authors: He, Y.
Lee, T. 
Yuan, S.Y.
Thong, P.S.P.
Watt, F. 
Leong, S.K. 
Shi, C.Y. 
Wong, P.T.H. 
Keywords: 6-Hydroxydopamine
Parkinson's disease
Substantia nigra
Issue Date: 1996
Citation: He, Y.,Lee, T.,Yuan, S.Y.,Thong, P.S.P.,Watt, F.,Leong, S.K.,Shi, C.Y.,Wong, P.T.H. (1996). Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: A nuclear microscopic study. Brain Research 735 (1) : 149-153. ScholarBank@NUS Repository.
Abstract: The trace elemental concentrations, including iron, in the substantia nigra (SN) of a 6-OHDA induced rat model of Parkinson's disease were measured using nuclear microscopy. Only rats that exhibited amphetamine induced rotation of more than 7 turns/min were used. The results showed that the iron levels were significantly increased in the 6-OHDA lesioned SN, compared with the intact contralateral SN, and the SN of normal control rats injected with ascorbic acid, which showed no significant difference in iron levels between injected and non-injected sides. In both 6-OHDA lesioned and ascorbic acid injected SN, there were no alterations in the levels of calcium, magnesium, copper and zinc. In the 6-OHDA lesioned SN there was an almost complete loss of tyrosine hydroxylase positive cells in the SN. These results suggested that the 6-OHDA induced dopaminergic cell death may be related to the increased iron.
Source Title: Brain Research
ISSN: 00068993
DOI: 10.1016/0006-8993(96)00313-7
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Sep 19, 2019

Page view(s)

checked on Sep 9, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.