Please use this identifier to cite or link to this item: https://doi.org/10.1016/0041-0101(94)90320-4
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dc.titleAction of Calloselasma rhodostoma (Malayan pit viper) venom on human blood coagulation and fibrinolysis using computerized thromboelastography (CTEG)
dc.contributor.authorDambisya, Y.M.
dc.contributor.authorLee, T.-L.
dc.contributor.authorGopalakrishnakone, P.
dc.date.accessioned2012-06-08T09:31:04Z
dc.date.available2012-06-08T09:31:04Z
dc.date.issued1994
dc.identifier.citationDambisya, Y.M., Lee, T.-L., Gopalakrishnakone, P. (1994). Action of Calloselasma rhodostoma (Malayan pit viper) venom on human blood coagulation and fibrinolysis using computerized thromboelastography (CTEG). Toxicon 32 (12) : 1619-1626. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-0101(94)90320-4
dc.identifier.issn00410101
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33910
dc.description.abstractThe effects of Malayan pit viper (Calloselasma rhodostoma) venom on human blood coagulation and fibrinolysis were studied in vitro using computerized thromboelastography. At low concentrations the venom had a coagulant effect shown by faster onset of the coagulation process (shortened SP and R), faster progress of the clot (increased angle and shortened K), and increased coagulation (TEG) index. The maximum amplitude (MA) was not affected, suggesting that the venom had no apparent effect on platelet function; and clot lysis was similar to that in the controls, suggesting that there was no primary fibrinolytic activity. At higher concentrations the venom had anticoagulant effects, SP and R were progressively shortened, but there was poor/no progress in the clot formed, evident from prolonged or absent K, diminished MA and reduced angle. These results show that C. rhodostoma venom has both coagulant and anticoagulant actions. The coagulant action may be due to Factor X activator predominance at low concentrations, while the anticoagulant action could be due to ancrod action. TEG is able to demonstrate the dual effect of this venom, previously described as a paradox, and may be a useful tool in the diagnosis and monitoring of envenomation patients.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0041-0101(94)90320-4
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentANATOMY
dc.contributor.departmentANAESTHESIA
dc.description.doi10.1016/0041-0101(94)90320-4
dc.description.sourcetitleToxicon
dc.description.volume32
dc.description.issue12
dc.description.page1619-1626
dc.description.codenTOXIA
dc.identifier.isiutA1994QB41600014
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