Please use this identifier to cite or link to this item: https://doi.org/10.1016/0041-0101(95)00053-O
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dc.titleButhus martensi Karsch venom: Prejunctional adrenergic activity in the rat isolated anococcygeus muscle
dc.contributor.authorGong, J.P.
dc.contributor.authorGopalakrishnakone, P.
dc.contributor.authorGwee, M.C.E.
dc.date.accessioned2012-06-08T09:30:53Z
dc.date.available2012-06-08T09:30:53Z
dc.date.issued1995
dc.identifier.citationGong, J.P., Gopalakrishnakone, P., Gwee, M.C.E. (1995). Buthus martensi Karsch venom: Prejunctional adrenergic activity in the rat isolated anococcygeus muscle. Toxicon 33 (9) : 1133-1139. ScholarBank@NUS Repository. https://doi.org/10.1016/0041-0101(95)00053-O
dc.identifier.issn00410101
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33899
dc.description.abstractThe effect of Buthus martensi Karsch venom (MKV) on adrenergic responses was investigated using the rat isolated anococcygeus muscle (Acm), since several scorpion venoms can cause peripheral sympathetic nerve stimulation with enhanced adrenergic responses. The effects of phentolamine (5 μM), guanethidine (5 μM), tetrodotoxin (2 μM), desipramine (1.5 μM) and reserpine pretreatment in vivo (5 mg/kg s.c. x 24 hr and 5 mg/kg i.p. x 3 hr) on contractile responses of the rat Acm to field stimulation, noradrenaline (3 μM), tyramine (10 μM), crude MKV (2 μg/ml), carbachol (3 μM) and potassium chloride (50 mM) were compared. Phentolamine, guanethidine, tetrodotoxin and reserpine pretreatment completely blocked the contractile responses of the Acm to MKV and to field stimulation but desipramine potentiated the responses. The responses to NA were completely blocked by phentolamine, but were potentiated by guanethidine, desipramine and reserpine pretreatment. The contractile responses to tyramine were completely blocked by phentolamine, desipramine and reserpine pretreatment. The low doses (0.1 μg/ml x 3) of MKV, which did not produce any observable increase in tone of the anococcygeus muscle, potentiated the contractile responses to field stimulation, but not the responses to exogenous NA. Thus, the adrenergic agonist action of MKV in the rat isolated anococcygeus muscle is mediated by some prejunctional mechanism(s) of action, presumably stimulating the release of the neurotransmitter noradrenaline.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0041-0101(95)00053-O
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentANATOMY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/0041-0101(95)00053-O
dc.description.sourcetitleToxicon
dc.description.volume33
dc.description.issue9
dc.description.page1133-1139
dc.description.codenTOXIA
dc.identifier.isiutA1995RW05600003
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