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https://doi.org/10.1016/S0006-8993(01)03159-6
Title: | Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain | Authors: | Zhu, X. Jin, S. Wong, P.T.H. Ng, Y.K. Lee, W.L. |
Keywords: | CNQX Cyclothiazide MK-801 Neurodegeneration Neuroprotection Non-NMDA receptor |
Issue Date: | 2001 | Citation: | Zhu, X., Jin, S., Wong, P.T.H., Ng, Y.K., Lee, W.L. (2001). Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain. Brain Research 922 (2) : 293-298. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-8993(01)03159-6 | Abstract: | We investigated the roles of ionotropic glutamate receptor subtypes in mediating striatal kainate injection-induced neuronal loss in rat forebrain, using subtype-specific antagonists and histochemical staining. Our study demonstrates that kainate injected unilaterally into the striatum induces a massive neuronal loss in the rat ipsilateral forebrain through activation of kainate receptors and, to a limited extent, a consequent involvement of M-methyl-D-aspartate (NMDA) receptors, whereas activation of α-amino-3-hydroxy-5-methylisoxazol-4-propionate (AMPA) receptors shows a neuroprotective effect. These and previous results suggest that three subtypes of ionotropic glutamate receptors play differential roles in mediating excitatory amino acid (EAA)-induced neurodegeneration. © 2001 Elsevier Science B.V. All rights reserved. | Source Title: | Brain Research | URI: | http://scholarbank.nus.edu.sg/handle/10635/33860 | ISSN: | 00068993 | DOI: | 10.1016/S0006-8993(01)03159-6 |
Appears in Collections: | Staff Publications |
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