Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0006-8993(01)03159-6
Title: Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain
Authors: Zhu, X.
Jin, S.
Wong, P.T.H. 
Ng, Y.K. 
Lee, W.L.
Keywords: CNQX
Cyclothiazide
MK-801
Neurodegeneration
Neuroprotection
Non-NMDA receptor
Issue Date: 2001
Citation: Zhu, X., Jin, S., Wong, P.T.H., Ng, Y.K., Lee, W.L. (2001). Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain. Brain Research 922 (2) : 293-298. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-8993(01)03159-6
Abstract: We investigated the roles of ionotropic glutamate receptor subtypes in mediating striatal kainate injection-induced neuronal loss in rat forebrain, using subtype-specific antagonists and histochemical staining. Our study demonstrates that kainate injected unilaterally into the striatum induces a massive neuronal loss in the rat ipsilateral forebrain through activation of kainate receptors and, to a limited extent, a consequent involvement of M-methyl-D-aspartate (NMDA) receptors, whereas activation of α-amino-3-hydroxy-5-methylisoxazol-4-propionate (AMPA) receptors shows a neuroprotective effect. These and previous results suggest that three subtypes of ionotropic glutamate receptors play differential roles in mediating excitatory amino acid (EAA)-induced neurodegeneration. © 2001 Elsevier Science B.V. All rights reserved.
Source Title: Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/33860
ISSN: 00068993
DOI: 10.1016/S0006-8993(01)03159-6
Appears in Collections:Staff Publications

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