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Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3940(98)00941-0
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dc.titlePropentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion
dc.contributor.authorWu, Y.-P.
dc.contributor.authorLing, E.-A.
dc.contributor.authorMcRae, A.
dc.contributor.authorRudolphi, K.
dc.date.accessioned2012-06-08T09:23:14Z
dc.date.available2012-06-08T09:23:14Z
dc.date.issued1999
dc.identifier.citationWu, Y.-P., Ling, E.-A., McRae, A., Rudolphi, K. (1999). Propentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion. Neuroscience Letters 260 (1) : 17-20. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3940(98)00941-0
dc.identifier.issn03043940
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33541
dc.description.abstractThis study examines the effect of Propentofylline (PPF) on reactive microglia in the lumbar spinal cord in rats following focal cerebral ischaemia produced by permanent occlusion of the middle cerebral artery (MCA). Our results showed that daily treatment of PPF beginning at 24 h after MCA occlusion for 2 or 4 consecutive days markedly suppressed the microglial response as detected immunohistochemically with OX-42. The most dramatic effect was the prevention of transformation of ramified microglia into amoeboidic form as well as formation of perineuronal microglia in close association with the soma of motoneurons. This has greatly amplified the potentiality of PPF used as a neuroprotective drug against microglia-related neuron damage induced by cerebral ischaemia.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3940(98)00941-0
dc.sourceScopus
dc.subjectAdenosine
dc.subjectFocal cerebral ischaemia
dc.subjectImmunohistochemistry
dc.subjectLumbar spinal cord
dc.subjectMicroglial activation
dc.subjectPropentofylline
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.doi10.1016/S0304-3940(98)00941-0
dc.description.sourcetitleNeuroscience Letters
dc.description.volume260
dc.description.issue1
dc.description.page17-20
dc.description.codenNELED
dc.identifier.isiut000078481100005
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