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https://doi.org/10.1016/S0006-8993(97)01552-7
DC Field | Value | |
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dc.title | A light and electron microscopic study of cytoplasmic phospholipase A2and cyclooxygenase-2 in the hippocampus after kainate lesions | |
dc.contributor.author | Sandhya, T.L. | |
dc.contributor.author | Ong, W.Y. | |
dc.contributor.author | Horrocks, L.A. | |
dc.contributor.author | Farooqui, A.A. | |
dc.date.accessioned | 2012-06-08T09:23:13Z | |
dc.date.available | 2012-06-08T09:23:13Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Sandhya, T.L., Ong, W.Y., Horrocks, L.A., Farooqui, A.A. (1998). A light and electron microscopic study of cytoplasmic phospholipase A2and cyclooxygenase-2 in the hippocampus after kainate lesions. Brain Research 788 (1-2) : 223-231. ScholarBank@NUS Repository. https://doi.org/10.1016/S0006-8993(97)01552-7 | |
dc.identifier.issn | 00068993 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/33540 | |
dc.description.abstract | The systemic administration of kainate (10 mg/ml) into adult Wistar rats produces seizures and neurodegeneration. We have studied the effect of kainate administration on cPLA2 and COX-2 immunoreactivities after 3 days and 1, 2, 4 and 11 weeks. The cPLA2 immunoreactivity was increased in hippocampal neurons at 1 and 3 days after kainate injection suggesting that PLA2 may be involved in neurodegeneration. Increased cPLA2 and COX-2 immunoreactivities in astrocytes at 1, 2, 4 and 11 weeks after kainate injection indicate an adaptive astrocytic response that may be associated with gliosis. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0006-8993(97)01552-7 | |
dc.source | Scopus | |
dc.subject | Arachidonic acid | |
dc.subject | Cyclooxygenase-2 | |
dc.subject | Excitotoxicity | |
dc.subject | Glial scar | |
dc.subject | Hippocampus | |
dc.subject | Phospholipase A2 | |
dc.subject | Reactive astrocyte | |
dc.type | Article | |
dc.contributor.department | ANATOMY | |
dc.description.doi | 10.1016/S0006-8993(97)01552-7 | |
dc.description.sourcetitle | Brain Research | |
dc.description.volume | 788 | |
dc.description.issue | 1-2 | |
dc.description.page | 223-231 | |
dc.description.coden | BRREA | |
dc.identifier.isiut | 000073584600029 | |
Appears in Collections: | Staff Publications |
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