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https://doi.org/10.1016/j.neulet.2006.08.032
Title: | RhoA protein expression correlates positively with degree of malignancy in astrocytomas | Authors: | Yan, B. Peh, B.K. Salto-Tellez, M. Chour, H.H. Lim, C. |
Keywords: | Astrocytomas Malignancy Protein expression RhoA |
Issue Date: | 2006 | Citation: | Yan, B., Peh, B.K., Salto-Tellez, M., Chour, H.H., Lim, C. (2006). RhoA protein expression correlates positively with degree of malignancy in astrocytomas. Neuroscience Letters 407 (2) : 124-126. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2006.08.032 | Abstract: | Astrocytic tumors are the most common intracranial neoplasms. Their prognoses correlate with a conventional morphological grading system that suffers from diagnostic subjectivity and hence, inter-observer inconsistency. A molecular marker that provides an objective reference for classification and prognostication of astrocytic tumors would be useful in diagnostic pathology. RhoA, a GTPase protein involved in cell migration and adhesion, has been shown to be upregulated in a variety of human cancers. Based on direct analysis of clinical materials, our study demonstrates increased expression of RhoA in high-grade astrocytomas. This observation may be relevant to astrocytoma biology and the development of potential therapeutics against high-grade astrocytomas. Of more immediate consequence, utilization of this marker may aid in the routine pathological grading (and hence prognostication) of astrocytomas. © 2006 Elsevier Ireland Ltd. All rights reserved. | Source Title: | Neuroscience Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/33190 | ISSN: | 03043940 | DOI: | 10.1016/j.neulet.2006.08.032 |
Appears in Collections: | Staff Publications |
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