Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/32501
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dc.titleGenetic Analysis of the Role of ARP2/3 Complex in border cell migration in Drosophila Melanogaster
dc.contributor.authorLU RUIFENG
dc.date.accessioned2012-04-30T18:01:48Z
dc.date.available2012-04-30T18:01:48Z
dc.date.issued2010-12-30
dc.identifier.citationLU RUIFENG (2010-12-30). Genetic Analysis of the Role of ARP2/3 Complex in border cell migration in Drosophila Melanogaster. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/32501
dc.description.abstractDuring oogenesis of Drosophila, one group of cells called border cells delaminate from the anterior epithelium and migrate to the oocyte in a stereotypic way. Border cells provide a good system to study cell migration in vivo due to their genetic tractability. arc-p34 was isolated from a border cell mutant clone screen due to its strong effect on border cell migration. arc-p34 encodes the Drosophila homolog of mammalian ARPC2, a component of Arp2/3 complex. When the level of various Arp2/3 components is reduced by RNAi, many border cell clusters fail to initiate the migration. If they initiate migration, these border cell clusters move much slower at first, but migrate normally later, suggesting distinct mechanisms differentially depend on Arp2/3. Single cell tracking shows that Arp2/3-impaired border cells are still motile, but show less directional movement. Thus Arp2/3 may be acting upstream or downstream of guidance cues to steer border cell migration.
dc.language.isoen
dc.subjectDrosophila, Oogenesis, Border cells, Collective cell migration, Arp2/3 complex, Time-lapse imaging
dc.typeThesis
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.supervisorRORTH, PERNILLE RAHBEK
dc.contributor.supervisorHE YUEHUI
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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