Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.brainres.2005.03.016
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dc.titleSimvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats
dc.contributor.authorWang, Q.
dc.contributor.authorMcLachlan, C.
dc.contributor.authorWong, P.T.-H.
dc.contributor.authorWang, P.H.
dc.date.accessioned2012-04-02T07:54:36Z
dc.date.available2012-04-02T07:54:36Z
dc.date.issued2005
dc.identifier.citationWang, Q., McLachlan, C., Wong, P.T.-H., Wang, P.H. (2005). Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats. Brain Research 1045 (1-2) : 229-233. ScholarBank@NUS Repository. https://doi.org/10.1016/j.brainres.2005.03.016
dc.identifier.issn00068993
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/32248
dc.description.abstractSprague-Dawley rats with unilateral lesion of the medial forebrain bundle by 6-hydroxydopamine showed marked decrease in the expression of dopamine D 1 and D2 receptors in the prefrontal cortex. Simvastatin (10 mg/kg/day for 4 weeks) restored receptor expression to control levels. Given the association of dopaminergic dysfunction in the prefrontal cortex and cognitive deficits in Parkinson's disease, these findings may have implication in the treatment of cognitive decline in advanced Parkinson's disease. © 2005 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.brainres.2005.03.016
dc.sourceScopus
dc.subject6-OHDA lesion
dc.subjectDopamine D1and D2receptors
dc.subjectDownregulation
dc.subjectParkinson's disease (PD)
dc.subjectSimvastatin, hydroxymethylglutaryl-coenzyme A reductase inhibitor
dc.subjectUpregulation
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.brainres.2005.03.016
dc.description.sourcetitleBrain Research
dc.description.volume1045
dc.description.issue1-2
dc.description.page229-233
dc.description.codenBRREA
dc.identifier.isiut000229530300027
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