Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbapap.2003.11.013
DC FieldValue
dc.titleTyrosine kinase inhibitors: A new approach for asthma
dc.contributor.authorWong, W.S.F.
dc.contributor.authorLeong, K.P.
dc.date.accessioned2012-04-02T07:44:04Z
dc.date.available2012-04-02T07:44:04Z
dc.date.issued2004
dc.identifier.citationWong, W.S.F., Leong, K.P. (2004). Tyrosine kinase inhibitors: A new approach for asthma. Biochimica et Biophysica Acta - Proteins and Proteomics 1697 (1-2) : 53-69. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbapap.2003.11.013
dc.identifier.issn15709639
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/32206
dc.description.abstractThe pathogenesis of allergic asthma involves the interplay of inflammatory cells and airway-resident cells, and of their secreted mediators including cytokines, chemokines, growth factors and inflammatory mediators. Receptor tyrosine kinases are important for the pathogenesis of airway remodeling. Activation of epidermal growth factor (EGF) receptor kinase and platelet-derived growth factor (PDGF) receptor kinase leads to hyperplasia of airway smooth muscle cells, epithelial cells and goblet cells. Stimulation of non-receptor tyrosine kinases (e.g. Lyn, Lck, Syk, ZAP-70, Fyn, Btk, Itk) is the earliest detectable signaling response upon antigen-induced immunoreceptor activation in inflammatory cells. Cytokine receptor dimerization upon ligand stimulation induces activation of Janus tyrosine kinases (JAKs), leading to recruitment and phosphorylation of signal transducer and activator of transcription (STAT) for selective gene expression regulation. Activation of chemokine receptors can trigger JAK-STAT pathway, Lck, Fyn, Lyn, Fgr, and Syk/Zap-70 to induce chemotaxis of inflammatory cells. Inhibitors of tyrosine kinases have been shown in vitro to block growth factor-induced hyperplasia of airway-resident cells; antigen-induced inflammatory cell activation and cytokine synthesis; cytokine-mediated pro-inflammatory gene expression in inflammatory and airway cells; and chemokine-induced chemotaxis of inflammatory cells. Recently, anti-inflammatory effects of tyrosine kinase inhibitors (e.g. genistein, tyrphostin AG213, piceatannol, tyrphostin AG490, WHI-P97, WHI-P131, Syk antisense) in animal models of allergic asthma have been reported. Therefore, development of inhibitors of tyrosine kinases can be a very attractive strategy for the treatment of asthma. © 2003 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbapap.2003.11.013
dc.sourceScopus
dc.subjectAHR
dc.subjectAirway hyperresponsiveness
dc.subjectAirway remodeling
dc.subjectAntigen-presenting cell
dc.subjectAPC
dc.subjectAsthma
dc.subjectBAL
dc.subjectBronchoalveolar lavage
dc.subjectChemokine
dc.subjectCytokine
dc.subjectGrowth factor
dc.subjectImmune receptor
dc.subjectImmunoreceptor tyrosine-based activation motifs
dc.subjectITAM
dc.subjectNF-κB
dc.subjectTyrosine kinase inhibitor
dc.typeConference Paper
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.bbapap.2003.11.013
dc.description.sourcetitleBiochimica et Biophysica Acta - Proteins and Proteomics
dc.description.volume1697
dc.description.issue1-2
dc.description.page53-69
dc.description.codenBBAPB
dc.identifier.isiut000220446500006
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