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Title: Serum DDT and DDE levels in Singapore general population
Authors: Luo, X.W.
Foo, S.C. 
Ong, H.Y. 
Keywords: Biological indicator
DDT exposure
Serum DDE
Serum DDT
Issue Date: 1997
Citation: Luo, X.W., Foo, S.C., Ong, H.Y. (1997). Serum DDT and DDE levels in Singapore general population. Science of the Total Environment 208 (1-2) : 97-104. ScholarBank@NUS Repository.
Abstract: A simple and fast method was used to determine 1,1'-(2,2,2- trichloroethylene)-bis(4-chlorobenzene) (DDT) and 1,1'-(2,2- dichloroethylidene)-bis(4-chlorobenzene) (DDE) in blood serum. Serum samples pre-treated with formic acid were extracted with n-hexane and determined by gas chromatography (GC-ECD), using PTE-5 capillary column. Detection limits for DDT and DDE were 0.5 ppb. Recovery with a fortified pooled sample at 1 ppb level was 107.0% for DDT and 106.0% for DDE. At 10 ppb level, the recoveries for DDT and DDE were 96.1% and 92.7%, respectively. Eighty-nine random blood samples collected from volunteers were analyzed. The geometric mean (GM) serum level of DDT was 1.9 ppb (0.2-8.9 ppb) and that of DDE was 10.8 ppb (1.5-88.1 ppb). There was a positive correlation between DDE and DDT level (r = 0.33, P < 0.01). The serum DDE level was positively correlated with age (r = 0.49, P < 0.01) and DDT x Age (r = 0.62, P < 0.01). No correlation was observed between DDT and age. These results suggest that DDE, a metabolite of DDT, is cumulative in the body. Therefore blood DDE could be used as a cumulative exposure marker for DDT, whereas blood DDT may be used to reflect its recent exposure.
Source Title: Science of the Total Environment
ISSN: 00489697
DOI: 10.1016/S0048-9697(97)00288-X
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