Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0198-8859(03)00078-8
DC Field | Value | |
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dc.title | Compression of functional space in HLA-A sequence diversity | |
dc.contributor.author | Zhao, B. | |
dc.contributor.author | Sakharkar, M.K. | |
dc.contributor.author | Kangueane, P. | |
dc.contributor.author | Png, A.E.H. | |
dc.contributor.author | Ren, E.C. | |
dc.contributor.author | Kolatkar, P.R. | |
dc.contributor.author | Mathura, V.S. | |
dc.date.accessioned | 2012-03-28T06:06:50Z | |
dc.date.available | 2012-03-28T06:06:50Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Zhao, B., Sakharkar, M.K., Kangueane, P., Png, A.E.H., Ren, E.C., Kolatkar, P.R., Mathura, V.S. (2003). Compression of functional space in HLA-A sequence diversity. Human Immunology 64 (7) : 718-728. ScholarBank@NUS Repository. https://doi.org/10.1016/S0198-8859(03)00078-8 | |
dc.identifier.issn | 01988859 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/31518 | |
dc.description.abstract | The major histocompatibility complex (MHC) is highly polymorphic and more than 1500 human MHC alleles are known to date. These alleles do not bind to a given peptide with identical affinity. Although MHC alleles are functionally related, it is difficult to quantify the functional variation between them. Three-dimensional structures of known MHC-peptide (MHCp) complexes suggest that specific peptide residues bind selectively to functional pockets in the binding groove. From a set of known MHCp structures we identified 21 critical polymorphic functional residue positions (CPFRP) that significantly reduced functional pocket variability to just 189 among 212 HLA-A alleles. Interestingly 101 HLA-A alleles clustered into 29 clusters such that the six functional pockets formed by the CPFRPs are identical within the cluster. © American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0198-8859(03)00078-8 | |
dc.source | Scopus | |
dc.subject | Functional pocket | |
dc.subject | MHC | |
dc.subject | Peptide binding | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY | |
dc.contributor.department | BIOINFORMATICS CENTRE | |
dc.contributor.department | GENOME INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.1016/S0198-8859(03)00078-8 | |
dc.description.sourcetitle | Human Immunology | |
dc.description.volume | 64 | |
dc.description.issue | 7 | |
dc.description.page | 718-728 | |
dc.description.coden | HUIMD | |
dc.identifier.isiut | 000183969300008 | |
Appears in Collections: | Staff Publications |
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