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Title: Immunodominance and immunoprotection of anti-viral specific CD8+ T cell response during HBV infection
Keywords: HBV, T cell, HLA, Hepatic flares, CXCL9, CXCL10
Issue Date: 1-Aug-2011
Citation: TAN ANTHONY TANOTO (2011-08-01). Immunodominance and immunoprotection of anti-viral specific CD8+ T cell response during HBV infection. ScholarBank@NUS Repository.
Abstract: This thesis focuses on two aspects of T cell responses during HBV infection, namely: 1) the factors that influence the immunodominant hierarchy of HBV-specific T cells and 2) immunoprotection of HBV-specific T cells during hepatic flares. In chapter 1, I analyzed the impact that host and virus variables exert on repertoire composition, quantity and qualitative functional ability of virus-specific T cells. I demonstrate that HBV-specific T cell quantity is largely determined by the virological and clinical profile of the patients, while the repertoire is shaped by the HLA-haplotype of the host. In chapter 2, I longitudinally studied the kinetics of immune activation during hepatic flares (HF) in chronic hepatitis B to determine whether HBV replication rebound and HF are associated with the activation of innate or adaptive immunological events or the recovery of HBV-specific immunity. I observed that both HBV replication rebound and HF were not associated with a recovery of peripheral HBV-specific T cell immunity. Instead, HF were strongly associated with elevated serum levels of CXCL-9 and CXCL-10, suggesting the occurrence of non-specific hepatic recruitment of T cells that could mediate the liver pathology.
Appears in Collections:Ph.D Theses (Open)

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