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Title: Translocation (8;22) in cold agglutinin disease associatedwith B-cell lymphoma
Authors: Chng, W.J.
Chen, J.
Lim, S. 
Kueh, Y.K. 
Lee, S.-H.
Chong, S.M. 
Issue Date: 2004
Citation: Chng, W.J., Chen, J., Lim, S., Kueh, Y.K., Lee, S.-H., Chong, S.M. (2004). Translocation (8;22) in cold agglutinin disease associatedwith B-cell lymphoma. Cancer Genetics and Cytogenetics 152 (1) : 66-69. ScholarBank@NUS Repository.
Abstract: Cold agglutinin disease (CAD) is a hemolytic anemia due to anti-red cell autoantibodies that are reactive at cold temperatures. In the elderly, it may be associated with underlying B-cell lymphoma, usually a lympho-plasmacytic lymphoma variant. We report a case of CAD in an elderly Indonesian female, which was associated with a B-cell lymphoma that showed a histologic appearance consistent with large-cell lymphoma. Cytogenetic analysis revealed the presence of trisomies 3 and 12, which have been reported previously in B-cell lymphoma associated with CAD. In addition, a t(8;22) was found in 24 out of 28 metaphases. Translocation (8;22) is associated with Burkitt lymphoma or acute lymphoblastic lymphoma, French-American-British subtype L3. It has not been previously reported in B-cell lymphoma asssociated with CAD, and could represent a blastic transformation of the underlying B-cell lymphoma. © 2004 Elsevier Inc. All rights reserved.
Source Title: Cancer Genetics and Cytogenetics
ISSN: 01654608
DOI: 10.1016/j.cancergencyto.2003.10.003
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