Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biocel.2006.09.007
DC FieldValue
dc.titleApoptosis in the pathophysiology of diabetes mellitus
dc.contributor.authorLee, S.C.
dc.contributor.authorPervaiz, S.
dc.date.accessioned2012-01-30T09:45:52Z
dc.date.available2012-01-30T09:45:52Z
dc.date.issued2007
dc.identifier.citationLee, S.C., Pervaiz, S. (2007). Apoptosis in the pathophysiology of diabetes mellitus. International Journal of Biochemistry and Cell Biology 39 (3) : 497-504. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2006.09.007
dc.identifier.issn13572725
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/30210
dc.description.abstractDiabetes mellitus is one of the most common non-communicable diseases, and if uncontrolled, targets multi-organ systems with serious debilitating and life-threatening sequela. Most diabetic cases fall under the Type 2 category, characterized by relatively late onset, development of insulin resistance and/or deficiency, and amyloidosis. Type 1 diabetes, on the other hand, manifests early during childhood and has an autoimmune component to it that causes a severe deficiency in the circulating levels of insulin. Despite the heterogeneity in etiology and clinical presentation, hyperglycemia is the most common metabolic abnormality in diabetic patients. At the molecular level, pancreatic β-cell loss by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the disease. Here, we provide a short review on the apoptotic death circuitry in the pathogenesis of diabetes. © 2006 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biocel.2006.09.007
dc.sourceScopus
dc.subjectApoptosis
dc.subjectDiabetes
dc.subjectGenetic control
dc.subjectMitosis
dc.subjectPancreatic β-cells
dc.typeReview
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.contributor.departmentPHYSIOLOGY
dc.description.doi10.1016/j.biocel.2006.09.007
dc.description.sourcetitleInternational Journal of Biochemistry and Cell Biology
dc.description.volume39
dc.description.issue3
dc.description.page497-504
dc.description.codenIJBBF
dc.identifier.isiut000244132700006
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