Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.biocel.2006.09.007
Title: | Apoptosis in the pathophysiology of diabetes mellitus | Authors: | Lee, S.C. Pervaiz, S. |
Keywords: | Apoptosis Diabetes Genetic control Mitosis Pancreatic β-cells |
Issue Date: | 2007 | Citation: | Lee, S.C., Pervaiz, S. (2007). Apoptosis in the pathophysiology of diabetes mellitus. International Journal of Biochemistry and Cell Biology 39 (3) : 497-504. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2006.09.007 | Abstract: | Diabetes mellitus is one of the most common non-communicable diseases, and if uncontrolled, targets multi-organ systems with serious debilitating and life-threatening sequela. Most diabetic cases fall under the Type 2 category, characterized by relatively late onset, development of insulin resistance and/or deficiency, and amyloidosis. Type 1 diabetes, on the other hand, manifests early during childhood and has an autoimmune component to it that causes a severe deficiency in the circulating levels of insulin. Despite the heterogeneity in etiology and clinical presentation, hyperglycemia is the most common metabolic abnormality in diabetic patients. At the molecular level, pancreatic β-cell loss by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the disease. Here, we provide a short review on the apoptotic death circuitry in the pathogenesis of diabetes. © 2006 Elsevier Ltd. All rights reserved. | Source Title: | International Journal of Biochemistry and Cell Biology | URI: | http://scholarbank.nus.edu.sg/handle/10635/30210 | ISSN: | 13572725 | DOI: | 10.1016/j.biocel.2006.09.007 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
65
checked on Jan 14, 2021
WEB OF SCIENCETM
Citations
60
checked on Jan 14, 2021
Page view(s)
245
checked on Jan 12, 2021
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.