Please use this identifier to cite or link to this item:
|Title:||Vitrification as a prospect for cryopreservation of tissue-engineered constructs||Authors:||Kuleshova, L.L.
|Issue Date:||2007||Citation:||Kuleshova, L.L., Gouk, S.S., Hutmacher, D.W. (2007). Vitrification as a prospect for cryopreservation of tissue-engineered constructs. Biomaterials 28 (9) : 1585-1596. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2006.11.047||Abstract:||Cryopreservation plays a significant function in tissue banking and will presume yet larger value when more and more tissue-engineered products will routinely enter the clinical arena. The most common concept underlying tissue engineering is to combine a scaffold (cellular solids) or matrix (hydrogels) with living cells to form a tissue-engineered construct (TEC) to promote the repair and regeneration of tissues. The scaffold and matrix are expected to support cell colonization, migration, growth and differentiation, and to guide the development of the required tissue. The promises of tissue engineering, however, depend on the ability to physically distribute the products to patients in need. For this reason, the ability to cryogenically preserve not only cells, but also TECs, and one day even whole laboratory-produced organs, may be indispensable. Cryopreservation can be achieved by conventional freezing and vitrification (ice-free cryopreservation). In this publication we try to define the needs versus the desires of vitrifying TECs, with particular emphasis on the cryoprotectant properties, suitable materials and morphology. It is concluded that the formation of ice, through both direct and indirect effects, is probably fundamental to these difficulties, and this is why vitrification seems to be the most promising modality of cryopreservation. © 2006 Elsevier Ltd. All rights reserved.||Source Title:||Biomaterials||URI:||http://scholarbank.nus.edu.sg/handle/10635/30196||ISSN:||01429612||DOI:||10.1016/j.biomaterials.2006.11.047|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 24, 2021
WEB OF SCIENCETM
checked on Feb 24, 2021
checked on Mar 3, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.