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Title: RhoA protein expression correlates positively with degree of malignancy in astrocytomas
Authors: Yan, B.
Peh, B.K. 
Salto-Tellez, M. 
Chour, H.H.
Lim, C. 
Keywords: Astrocytomas
Protein expression
Issue Date: 2006
Citation: Yan, B., Peh, B.K., Salto-Tellez, M., Chour, H.H., Lim, C. (2006). RhoA protein expression correlates positively with degree of malignancy in astrocytomas. Neuroscience Letters 407 (2) : 124-126. ScholarBank@NUS Repository.
Abstract: Astrocytic tumors are the most common intracranial neoplasms. Their prognoses correlate with a conventional morphological grading system that suffers from diagnostic subjectivity and hence, inter-observer inconsistency. A molecular marker that provides an objective reference for classification and prognostication of astrocytic tumors would be useful in diagnostic pathology. RhoA, a GTPase protein involved in cell migration and adhesion, has been shown to be upregulated in a variety of human cancers. Based on direct analysis of clinical materials, our study demonstrates increased expression of RhoA in high-grade astrocytomas. This observation may be relevant to astrocytoma biology and the development of potential therapeutics against high-grade astrocytomas. Of more immediate consequence, utilization of this marker may aid in the routine pathological grading (and hence prognostication) of astrocytomas. © 2006 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
ISSN: 03043940
Appears in Collections:Staff Publications

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