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Title: Pathobiological predictors of behavior in invasive lobular carcinoma of the breast
Keywords: Breast, cancer, lobular, pleomorphic, triple negativity, basal
Issue Date: 20-Jul-2011
Citation: CHEOK POH YIAN (2011-07-20). Pathobiological predictors of behavior in invasive lobular carcinoma of the breast. ScholarBank@NUS Repository.
Abstract: Invasive lobular carcinoma (ILC) accounts for approximately 10 % of invasive breast carcinoma and its incidence appears to be increasing. This work presents a comprehensive study of pathological features and outcome of ILC in a large series of Singaporean women. The clinicopathological characteristics and immunohistochemical profiles of ILC were assessed including its association with triple negativity and basal-like phenotype by the use of immuno-markers: Estrogen Receptor (ER), Progesterone Receptor (PR), HER-2, Mammaglobin, Ki-67, Cytokeratin High Molecular Weight (CK HMW), Cytokeratin 14 (CK14) and Epidermal Growth Factor Receptor (EGFR). In Singapore, the incidence of ILC is relatively low, similar to other Asian countries. The pleomorphic variant, triple negativity and basal phenotype in ILC were associated with worse characteristics but have no differences with regard to patient survival. Tumour size, histologic grade, lymph node status remained as important independent prognostic characteristics.
Appears in Collections:Master's Theses (Open)

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