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Title: Crystallization of Glycine at Liquid-Liquid Interface - an Experimental Perspective
Keywords: Crystallization,Glycine,Liquid Interface
Issue Date: 19-Aug-2011
Citation: RENO ANTONY LOUIS LEON (2011-08-19). Crystallization of Glycine at Liquid-Liquid Interface - an Experimental Perspective. ScholarBank@NUS Repository.
Abstract: In an attempt to improve the current understanding of polymorphic nucleation and crystal growth in organic crystallization processes, the effect of solvent on polymorphic selection has gained tremendous interest in recent years; especially in studies of crystallization at the vicinity of liquid-liquid interfaces, which is a complex and poorly understood phenomenon involving a host of interacting processes such as interfacial molecular recognition, exchange of material across phases and phase transformation. Conventional experimental tools that employ stirred tanks or flasks for both production or research and development, often involve heterogeneous spatial and temporal distribution of process parameters. This largely hinders the control and resolution required to acquire mechanistic insight into the process. This thesis reports a simple and effective method to probe anti-solvent induced crystal nucleation and growth at liquid-liquid interfaces at good spatial and temporal resolution coupled with real-time high speed optical microscopy. Glycine is used as the model solute for crystallization. It is observed that the liquid interface serves as a potential site where crystals first appear and grow. The size and morphology of the formed crystals are closely related to the anti-solvent addition rate. Furthermore, the dominant polymorphic form might also be influenced by the rate of addition of anti-solvent (ethanol). Thus we report that a change in the processing condition coupled with the presence of an interface might causes a polymorphic shift in the dominant crystal form, in this case from a-glycine to ?-glycine. Dynamic changes in crystal morphology and concomitant polymorphism of glycine have also been addressed. This mode of crystallization could enable better observation and improved understanding of crystallization at liquid-liquid interfaces.
Appears in Collections:Master's Theses (Open)

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