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Title: Metabolic profiling of colorectal cancer
Keywords: colorectal cancer, metabolic profiling, metabolites, eicosanoids, mass spectrometry, biomarkers
Issue Date: 20-Jun-2011
Citation: MAINAK MAL (2011-06-20). Metabolic profiling of colorectal cancer. ScholarBank@NUS Repository.
Abstract: Colorectal cancer (CRC) is the second most common form of cancer in the world and the most common cancer in Singapore. The limitations of the currently available methods and biomarkers for CRC management highlight the necessity of finding novel markers. In this study metabolic profiling of CRC was carried out with a non targeted as well as a targeted approach to identify metabolite based markers. Non targeted metabolic profiling of CRC was carried out using three analytical platforms viz. GC/MS, HR-MAS NMR and GC?GC/TOFMS. Keeping in mind the strong association between inflammation and CRC and the significant role played by eicosanoids in it, we carried out targeted metabolic profiling of eight relevant eicosanoids and major metabolic precursor arachidonic acid using UPLC/MS/MS. Metabolic profiling of CRC led to the identification of marker metabolites and revealed metabolic perturbations that may be exploited for future biomarker research or finding new therapeutic strategies.
Appears in Collections:Ph.D Theses (Open)

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