Please use this identifier to cite or link to this item:
|Title:||Superoxide anion inhibits drug-induced tumor cell death||Authors:||Pervaiz, S.
|Issue Date:||1999||Citation:||Pervaiz, S., Hirpara, J.L., Ramalingam, J.K., Clement, M.-V. (1999). Superoxide anion inhibits drug-induced tumor cell death. FEBS Letters 459 (3) : 343-348. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01258-2||Abstract:||Intracellular superoxide (O2(.-)) was manipulated in M14 melanoma cells by overexpression or repression of Cu/Zn SOD using a tetracycline-inducible expression system. Scavenging intracellular O2(.-) increased tumor cell sensitivity to daunorubicin, etoposide, and pMC540, whereas expression of the antisense SOD mRNA significantly decreased cell sensitivity to drug treatment. Whereas Cu/Zn SOD overexpressing cells exhibited higher activation of the executioner caspase 3 upon drug exposure, caspase 3 activation was significantly lower when Cu/Zn SOD was repressed by antisense expression. These data show that intracellular O2(.-) regulates tumor cell response to drug-induced cell death via a direct or indirect effect on the caspase activation pathway. Copyright (C) 1999 Federation of European Biochemical Societies.||Source Title:||FEBS Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/29733||ISSN:||00145793||DOI:||10.1016/S0014-5793(99)01258-2|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 5, 2021
WEB OF SCIENCETM
checked on Apr 28, 2021
checked on May 6, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.