Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0014-5793(99)01258-2
DC Field | Value | |
---|---|---|
dc.title | Superoxide anion inhibits drug-induced tumor cell death | |
dc.contributor.author | Pervaiz, S. | |
dc.contributor.author | Hirpara, J.L. | |
dc.contributor.author | Ramalingam, J.K. | |
dc.contributor.author | Clement, M.-V. | |
dc.date.accessioned | 2011-12-07T08:16:59Z | |
dc.date.available | 2011-12-07T08:16:59Z | |
dc.date.issued | 1999 | |
dc.identifier.citation | Pervaiz, S., Hirpara, J.L., Ramalingam, J.K., Clement, M.-V. (1999). Superoxide anion inhibits drug-induced tumor cell death. FEBS Letters 459 (3) : 343-348. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01258-2 | |
dc.identifier.issn | 00145793 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/29733 | |
dc.description.abstract | Intracellular superoxide (O2(.-)) was manipulated in M14 melanoma cells by overexpression or repression of Cu/Zn SOD using a tetracycline-inducible expression system. Scavenging intracellular O2(.-) increased tumor cell sensitivity to daunorubicin, etoposide, and pMC540, whereas expression of the antisense SOD mRNA significantly decreased cell sensitivity to drug treatment. Whereas Cu/Zn SOD overexpressing cells exhibited higher activation of the executioner caspase 3 upon drug exposure, caspase 3 activation was significantly lower when Cu/Zn SOD was repressed by antisense expression. These data show that intracellular O2(.-) regulates tumor cell response to drug-induced cell death via a direct or indirect effect on the caspase activation pathway. Copyright (C) 1999 Federation of European Biochemical Societies. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-5793(99)01258-2 | |
dc.source | Scopus | |
dc.subject | Apoptosis | |
dc.subject | Caspase | |
dc.subject | Chemotherapy | |
dc.subject | Superoxide anion | |
dc.type | Article | |
dc.contributor.department | PHYSIOLOGY | |
dc.contributor.department | NATIONAL UNIVERSITY MEDICAL INSTITUTES | |
dc.description.doi | 10.1016/S0014-5793(99)01258-2 | |
dc.description.sourcetitle | FEBS Letters | |
dc.description.volume | 459 | |
dc.description.issue | 3 | |
dc.description.page | 343-348 | |
dc.description.coden | FEBLA | |
dc.identifier.isiut | 000083204500012 | |
Appears in Collections: | Staff Publications |
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