Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-5793(99)01258-2
DC FieldValue
dc.titleSuperoxide anion inhibits drug-induced tumor cell death
dc.contributor.authorPervaiz, S.
dc.contributor.authorHirpara, J.L.
dc.contributor.authorRamalingam, J.K.
dc.contributor.authorClement, M.-V.
dc.date.accessioned2011-12-07T08:16:59Z
dc.date.available2011-12-07T08:16:59Z
dc.date.issued1999
dc.identifier.citationPervaiz, S., Hirpara, J.L., Ramalingam, J.K., Clement, M.-V. (1999). Superoxide anion inhibits drug-induced tumor cell death. FEBS Letters 459 (3) : 343-348. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(99)01258-2
dc.identifier.issn00145793
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/29733
dc.description.abstractIntracellular superoxide (O2(.-)) was manipulated in M14 melanoma cells by overexpression or repression of Cu/Zn SOD using a tetracycline-inducible expression system. Scavenging intracellular O2(.-) increased tumor cell sensitivity to daunorubicin, etoposide, and pMC540, whereas expression of the antisense SOD mRNA significantly decreased cell sensitivity to drug treatment. Whereas Cu/Zn SOD overexpressing cells exhibited higher activation of the executioner caspase 3 upon drug exposure, caspase 3 activation was significantly lower when Cu/Zn SOD was repressed by antisense expression. These data show that intracellular O2(.-) regulates tumor cell response to drug-induced cell death via a direct or indirect effect on the caspase activation pathway. Copyright (C) 1999 Federation of European Biochemical Societies.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-5793(99)01258-2
dc.sourceScopus
dc.subjectApoptosis
dc.subjectCaspase
dc.subjectChemotherapy
dc.subjectSuperoxide anion
dc.typeArticle
dc.contributor.departmentPHYSIOLOGY
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1016/S0014-5793(99)01258-2
dc.description.sourcetitleFEBS Letters
dc.description.volume459
dc.description.issue3
dc.description.page343-348
dc.description.codenFEBLA
dc.identifier.isiut000083204500012
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