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Title: Superoxide anion inhibits drug-induced tumor cell death
Authors: Pervaiz, S. 
Hirpara, J.L. 
Ramalingam, J.K. 
Clement, M.-V. 
Keywords: Apoptosis
Superoxide anion
Issue Date: 1999
Citation: Pervaiz, S., Hirpara, J.L., Ramalingam, J.K., Clement, M.-V. (1999). Superoxide anion inhibits drug-induced tumor cell death. FEBS Letters 459 (3) : 343-348. ScholarBank@NUS Repository.
Abstract: Intracellular superoxide (O2(.-)) was manipulated in M14 melanoma cells by overexpression or repression of Cu/Zn SOD using a tetracycline-inducible expression system. Scavenging intracellular O2(.-) increased tumor cell sensitivity to daunorubicin, etoposide, and pMC540, whereas expression of the antisense SOD mRNA significantly decreased cell sensitivity to drug treatment. Whereas Cu/Zn SOD overexpressing cells exhibited higher activation of the executioner caspase 3 upon drug exposure, caspase 3 activation was significantly lower when Cu/Zn SOD was repressed by antisense expression. These data show that intracellular O2(.-) regulates tumor cell response to drug-induced cell death via a direct or indirect effect on the caspase activation pathway. Copyright (C) 1999 Federation of European Biochemical Societies.
Source Title: FEBS Letters
ISSN: 00145793
DOI: 10.1016/S0014-5793(99)01258-2
Appears in Collections:Staff Publications

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