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Title: The Functional Investigation of Forkhead Factor FOXQ1 In Human Breast and Colon Cancers'
Keywords: FOXQ1, Epithelial to Mesenchymal Transition, Cancer, E-cadherin
Issue Date: 9-May-2011
Citation: QIAO YUANYUAN (2011-05-09). The Functional Investigation of Forkhead Factor FOXQ1 In Human Breast and Colon Cancers'. ScholarBank@NUS Repository.
Abstract: Forkhead transcription factor, such as FOXC2, has been implicated in regulating cancer epithelial to mesenchymal transition (EMT) and cancer metastasis. In this study, another forkhead transcription factor, FOXQ1 has been identified to be overexpressed in colon cancer and invasive breast cancer cells associated with aggressive phenotypes. The main objective of this study is to characterize the functional roles of FOXQ1 in breast and colon cancers. Specifically, the regulation and function of FOXQ1 protein as a transcription factor for modulating EMT progression in breast and colon cancers were studied. Given that FOXQ1 is highly expressed in basal-like breast cancer and most of the colorectal cancer, we hypothesized that FOXQ1 may be implicated in cancer progression. To address the hypothesis, an ectopic expression system and RNAi knockdown system was used to study FOXQ1 in human cancer and immortalized epithelial cell lines. In addition, the downstream transcriptional targets of FOXQ1 have been identified in both breast and colorectal cancer cells. The evidence presented in this study strongly suggest that FOXQ1 is an important forkhead factor in cancer progression and may serve as a potential therapeutic target.
Appears in Collections:Ph.D Theses (Open)

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