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Title: Characterisation of Lung Dendritic Cell Function in a Mouse Model of Influenza
Keywords: Influenza, Dendritic Cell, Lung, Virus
Issue Date: 7-Jul-2011
Citation: HO WEI SHIONG ADRIAN (2011-07-07). Characterisation of Lung Dendritic Cell Function in a Mouse Model of Influenza. ScholarBank@NUS Repository.
Abstract: Although several studies have demonstrated a critical role of DCs for the initiation of cytotoxic T-cell responses against the influenza virus, the underlying mechanisms for its potent ability to prime CD8 T-cells remain poorly understood. Using a novel approach of fluorescent lipophilic dye-labelled influenza virus, we demonstrate that CD11blo/negCD103+ DCs are the dominant lung DC population transporting influenza virus to the posterior mediastinal lymph node as early as 20 hours after the infection. By contrast, CD11bhiCD103neg DCs although more efficient for taking up the virus within the lung, migrate poorly to the lymph node and remain in the lung to produce pro-inflammatory cytokines instead. CD11blo/negCD103+ DCs efficiently load viral peptide onto MHC-1 complexes and therefore uniquely possess the capacity to potently induce proliferation of naive CD8 T-cells. In addition, the peptide transporter TAP1/TAP2 is constitutively expressed at higher level in CD11blo/negCD103+ DCs, providing first evidence of a distinct regulation of the antigen-processing pathway in these cells.
Appears in Collections:Ph.D Theses (Open)

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