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dc.titleCharacterisation of Lung Dendritic Cell Function in a Mouse Model of Influenza
dc.contributor.authorHO WEI SHIONG ADRIAN
dc.identifier.citationHO WEI SHIONG ADRIAN (2011-07-07). Characterisation of Lung Dendritic Cell Function in a Mouse Model of Influenza. ScholarBank@NUS Repository.
dc.description.abstractAlthough several studies have demonstrated a critical role of DCs for the initiation of cytotoxic T-cell responses against the influenza virus, the underlying mechanisms for its potent ability to prime CD8 T-cells remain poorly understood. Using a novel approach of fluorescent lipophilic dye-labelled influenza virus, we demonstrate that CD11blo/negCD103+ DCs are the dominant lung DC population transporting influenza virus to the posterior mediastinal lymph node as early as 20 hours after the infection. By contrast, CD11bhiCD103neg DCs although more efficient for taking up the virus within the lung, migrate poorly to the lymph node and remain in the lung to produce pro-inflammatory cytokines instead. CD11blo/negCD103+ DCs efficiently load viral peptide onto MHC-1 complexes and therefore uniquely possess the capacity to potently induce proliferation of naive CD8 T-cells. In addition, the peptide transporter TAP1/TAP2 is constitutively expressed at higher level in CD11blo/negCD103+ DCs, providing first evidence of a distinct regulation of the antigen-processing pathway in these cells.
dc.subjectInfluenza, Dendritic Cell, Lung, Virus
dc.contributor.departmentNUS GRAD SCH FOR INTEGRATIVE SCI & ENGG
dc.contributor.supervisorKEMENY, DAVID MICHAEL
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
Appears in Collections:Ph.D Theses (Open)

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