Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.transproceed.2003.11.001
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dc.titleEffectiveness of transient immunosuppression using cyclosporine for xenomyoblast transplantation for cardiac repair
dc.contributor.authorHaider, H.Kh.
dc.contributor.authorJiang, S.J.
dc.contributor.authorYe, L.
dc.contributor.authorSim, E.K.W.
dc.contributor.authorAziz, S.
dc.contributor.authorLaw, P.K.
dc.date.accessioned2011-11-30T06:34:40Z
dc.date.available2011-11-30T06:34:40Z
dc.date.issued2004
dc.identifier.citationHaider, H.Kh., Jiang, S.J., Ye, L., Sim, E.K.W., Aziz, S., Law, P.K. (2004). Effectiveness of transient immunosuppression using cyclosporine for xenomyoblast transplantation for cardiac repair. Transplantation Proceedings 36 (1) : 232-235. ScholarBank@NUS Repository. https://doi.org/10.1016/j.transproceed.2003.11.001
dc.identifier.issn00411345
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/29494
dc.description.abstractWe studied the survival of human myoblast for cellular myocardial reconstruction in a porcine model of chronic myocardial ischemia with immune tolerance using transient immunosuppression. A porcine model of chronic cardiac ischemia was created in 10 pigs (DMEM medium-injected n = 4; myoblast transplanted n = 6) by clamping ameroid ring around left circumflex coronary artery. Three weeks later, 3 × 108 human myoblasts carrying lac-z reporter gene were transplanted in multiple sites (0.25 mL each) into the left ventricular wall. Immunosuppression was achieved with 5 mg/kg cyclosporine for 6 weeks after cell transplantation. After animals were euthanized between 6 and 30 weeks after cell transplantation; the heart was removed for histological studies. Discontinuation of immunosuppression after 6 weeks of cell transplantation did not result in donor cell rejection. The lac-z-positive donor cells were detected in porcine host cardiac tissue for up to 30 weeks posttransplantation, expressing human skeletal myosin heavy chain. The results highlight the effectiveness of transient immunosuppression for myoblast transplantation for cardiac repair.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.transproceed.2003.11.001
dc.sourceScopus
dc.typeConference Paper
dc.contributor.departmentSURGERY
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.description.doi10.1016/j.transproceed.2003.11.001
dc.description.sourcetitleTransplantation Proceedings
dc.description.volume36
dc.description.issue1
dc.description.page232-235
dc.description.codenTRPPA
dc.identifier.isiut000188758100070
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