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Title: Renal impairment and diabetes mellitus after liver transplant
Authors: Sutedja, D.S.
Wai, C.-T.
Teoh, K.-F.
Lee, H.-L.
Dacosta, M.
Lee, M.
Kaur, M.
Lee, Y.-M.
Lee, K.-H. 
Mak, K.
Quak, S.-H. 
Isaac, J. 
Lim, S.-G. 
Prabhakaran, K. 
Issue Date: 2004
Citation: Sutedja, D.S., Wai, C.-T., Teoh, K.-F., Lee, H.-L., Dacosta, M., Lee, M., Kaur, M., Lee, Y.-M., Lee, K.-H., Mak, K., Quak, S.-H., Isaac, J., Lim, S.-G., Prabhakaran, K. (2004). Renal impairment and diabetes mellitus after liver transplant. Transplantation Proceedings 36 (8) : 2324-2327. ScholarBank@NUS Repository.
Abstract: One of the major concerns in liver transplant patients who survive past 1 year posttransplant is the development of chronic diseases. We studied two important clinical conditions that can have a chronic course--renal impairment and diabetes mellitus--among long-term liver transplant survivors. All adult patients transplanted and followed for at least 1 year were evaluated for clinical status, blood tests, and imaging studies. The occurrence and development of renal impairment, defined as a serum creatinine above 125 μmol/L or creatinine clearance less than 75 mL/min, or diabetes mellitus were evaluated for contributing factors. The 35 evaluated patients of mean age at transplant of 50 years had a mean follow-up duration of 45 months. The incidence of posttransplant renal impairment was 22.8% at 1 year and 47.6% at 3 years. This disorder was associated with pretransplant renal impairment and with a diagnosis of diabetes. Posttransplant diabetes mellitus was observed in 48.6% with 41.1% resolving over time. Posttransplant renal impairment appears to be a potential long-term problem. Although this relates to pretransplant conditions, longer follow-up is required to examine whether posttransplant factors contribute to its progression.
Source Title: Transplantation Proceedings
ISSN: 00411345
DOI: 10.1016/j.transproceed.2004.06.059
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