Please use this identifier to cite or link to this item: https://doi.org/10.1016/0006-2952(95)00111-C
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dc.titleEffects of adenosine receptor agonists on nitric oxide release in mouse during endotoxemia
dc.contributor.authorWei, M.H.
dc.contributor.authorHoon, E.K.
dc.contributor.authorSing, S.N.
dc.contributor.authorMoochhala, S.
dc.date.accessioned2011-11-30T06:34:09Z
dc.date.available2011-11-30T06:34:09Z
dc.date.issued1995
dc.identifier.citationWei, M.H., Hoon, E.K., Sing, S.N., Moochhala, S. (1995). Effects of adenosine receptor agonists on nitric oxide release in mouse during endotoxemia. Biochemical Pharmacology 50 (1) : 45-47. ScholarBank@NUS Repository. https://doi.org/10.1016/0006-2952(95)00111-C
dc.identifier.issn00062952
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/29451
dc.description.abstractThe effects of adenosine receptor agonists on plasma NO(x)- (NO2- and NO3-) production in mice treated with lipopolysaccharide (LPS) were investigated. NO(x)- is the stable decomposition product of nitric oxide (NO), which can be measured as a marker of NO production. Injection of the mice with LPS resulted in increased plasma NO(x)- concentration, reaching a peak after 8 hr (38 times basal level) and then declining slowly. Pretreatment with the adenosine agonists R-phenylisopropyladenosine (R-PIA), 5'-N-ethylcarboxamidoadenosine (NECA), 5'-(N-cyclopropyl)carboxamidoadenosine (CPCA) and N6-cyclohexyladenosine (CHA) 1 hr before LPS administration caused a dose-dependent reduction of plasma NO(x)- concentration. The rank order of inhibitory potency was NECA ≥ R-PIA > CPCA > CHA, which is characteristic of neither A1 nor A2 receptors.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0006-2952(95)00111-C
dc.sourceScopus
dc.subjectadenosine agonist
dc.subjectendotoxemia
dc.subjectlipopolysaccharide
dc.subjectnitric oxide
dc.typeArticle
dc.contributor.departmentSURGERY
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/0006-2952(95)00111-C
dc.description.sourcetitleBiochemical Pharmacology
dc.description.volume50
dc.description.issue1
dc.description.page45-47
dc.description.codenBCPCA
dc.identifier.isiutA1995RH27200006
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