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Title: Effects of adenosine receptor agonists on nitric oxide release in mouse during endotoxemia
Authors: Wei, M.H.
Hoon, E.K. 
Sing, S.N. 
Moochhala, S. 
Keywords: adenosine agonist
nitric oxide
Issue Date: 1995
Citation: Wei, M.H., Hoon, E.K., Sing, S.N., Moochhala, S. (1995). Effects of adenosine receptor agonists on nitric oxide release in mouse during endotoxemia. Biochemical Pharmacology 50 (1) : 45-47. ScholarBank@NUS Repository.
Abstract: The effects of adenosine receptor agonists on plasma NO(x)- (NO2- and NO3-) production in mice treated with lipopolysaccharide (LPS) were investigated. NO(x)- is the stable decomposition product of nitric oxide (NO), which can be measured as a marker of NO production. Injection of the mice with LPS resulted in increased plasma NO(x)- concentration, reaching a peak after 8 hr (38 times basal level) and then declining slowly. Pretreatment with the adenosine agonists R-phenylisopropyladenosine (R-PIA), 5'-N-ethylcarboxamidoadenosine (NECA), 5'-(N-cyclopropyl)carboxamidoadenosine (CPCA) and N6-cyclohexyladenosine (CHA) 1 hr before LPS administration caused a dose-dependent reduction of plasma NO(x)- concentration. The rank order of inhibitory potency was NECA ≥ R-PIA > CPCA > CHA, which is characteristic of neither A1 nor A2 receptors.
Source Title: Biochemical Pharmacology
ISSN: 00062952
DOI: 10.1016/0006-2952(95)00111-C
Appears in Collections:Staff Publications

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