Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ophtha.2004.10.039
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dc.titleCardiovascular risk factors for retinal vein occlusion and arteriolar emboli: The atherosclerosis risk in communities & cardiovascular health studies
dc.contributor.authorWong, T.Y.
dc.contributor.authorLarsen, E.K.M.
dc.contributor.authorKlein, R.
dc.contributor.authorKlein, B.E.K.
dc.contributor.authorHubbard, L.D.
dc.contributor.authorMitchell, P.
dc.contributor.authorCouper, D.J.
dc.contributor.authorSiscovick, D.S.
dc.contributor.authorSharrett, A.R.
dc.date.accessioned2011-11-30T02:05:39Z
dc.date.available2011-11-30T02:05:39Z
dc.date.issued2005
dc.identifier.citationWong, T.Y., Larsen, E.K.M., Klein, R., Klein, B.E.K., Hubbard, L.D., Mitchell, P., Couper, D.J., Siscovick, D.S., Sharrett, A.R. (2005). Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: The atherosclerosis risk in communities & cardiovascular health studies. Ophthalmology 112 (4) : 540-547. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ophtha.2004.10.039
dc.identifier.issn01616420
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/29133
dc.description.abstractObjective: To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease. Design: Population-based cross-sectional study. Participants: Pooled from the Atherosclerosis Risk in Communities Study (n = 12 642; mean age, 60 years) and the Cardiovascular Health Study (n = 2824; mean age, 79 years). Methods: Retinal vein occlusion and arteriolar emboli were identified from a single nonmydriatic retinal photograph using a standardized protocol. Photographs were also graded for arteriovenous nicking and focal arteriolar narrowing. All participants had a comprehensive systemic evaluation, including standardized carotid ultrasonography. Main Outcome Measures: Retinal vein occlusion and arteriolar emboli. Results: Prevalences of retinal vein occlusion and arteriolar emboli were 0.3% (n = 39 cases) and 0.2% (n = 34 cases), respectively. After adjusting for age, retinal vein occlusion was associated with hypertension (odds ratio [OR], 2.96; 95% confidence interval [CI], 1.43-6.14), systolic blood pressure (BP) (OR, 4.12; 95% CI, 1.40-12.16; highest quartile vs. lowest), diastolic BP (OR, 2.64; 95% CI, 1.07-6.46; highest quartile vs. lowest), carotid artery plaque (OR, 5.62; 95% CI, 2.60-12.16), body mass index (OR, 3.88; 95% CI, 1.23-12.18; highest quartile vs. lowest), plasma fibrinogen (OR, 3.29; 95% CI, 1.08-10.02; highest quartile vs. lowest), arteriovenous nicking (OR, 4.09; 95% CI, 2.00-8.36), and focal arteriolar narrowing (OR, 5.17; 95% CI, 2.59-10.29). After adjusting for age, retinal arteriolar emboli were associated with hypertension (OR, 3.14; 95% CI, 1.44-6.84), systolic BP (OR, 3.46; 95% CI, 1.13-10.65; highest quartile vs. lowest), prevalent coronary heart disease (OR, 2.33; 95% CI, 1.01-5.42), carotid artery plaque (OR, 4.62; 95% CI, 1.85-11.57), plasma lipoprotein (a) (OR, 3.69; 95% CI, 1.20-11.41; highest quartile vs. lowest), plasma fibrinogen (OR, 3.09; 95% CI, 0.98-9.76; highest quartile vs. lowest), and current cigarette smoking (OR, 3.08; 95% CI, 1.47-6.47). Approximately a quarter of participants with retinal vein occlusion and arteriolar emboli had evidence of carotid artery plaque as defined from ultrasound. Conclusions: Retinal vein occlusion and retinal arteriolar emboli are associated with carotid artery disease, hypertension, and other cardiovascular risk factors. © 2005 by the American Academy of Ophthalmology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ophtha.2004.10.039
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1016/j.ophtha.2004.10.039
dc.description.sourcetitleOphthalmology
dc.description.volume112
dc.description.issue4
dc.description.page540-547
dc.description.codenOPHTD
dc.identifier.isiut000227962200003
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