Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.atherosclerosis.2009.08.012
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dc.titleIs uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study
dc.contributor.authorSeet, R.C.S.
dc.contributor.authorKasiman, K.
dc.contributor.authorGruber, J.
dc.contributor.authorTang, S.-Y.
dc.contributor.authorHalliwell, B.
dc.contributor.authorWong, M.-C.
dc.contributor.authorChang, H.-M.
dc.contributor.authorChan, Y.-H.
dc.contributor.authorChen, C.P.
dc.date.accessioned2011-11-29T06:10:21Z
dc.date.available2011-11-29T06:10:21Z
dc.date.issued2010
dc.identifier.citationSeet, R.C.S., Kasiman, K., Gruber, J., Tang, S.-Y., Halliwell, B., Wong, M.-C., Chang, H.-M., Chan, Y.-H., Chen, C.P. (2010). Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study. Atherosclerosis 209 (1) : 215-219. ScholarBank@NUS Repository. https://doi.org/10.1016/j.atherosclerosis.2009.08.012
dc.identifier.issn00219150
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28863
dc.description.abstractContrasting observations have been made between serum urate and ischemic stroke outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is associated with stroke outcomes, a prospective follow-up study was performed in a cohort of Asian patients with ischemic stroke. Patients diagnosed with transient ischemic attack, first or recurrent ischemic stroke were included in this study. Serum urate, measured using high-performance liquid chromatography, was correlated with 12-month functional and vascular stroke outcomes. Poor functional outcome was defined as a modified Rankin scale exceeding 2 and vascular outcome was defined as a composite of recurrent stroke, myocardial infarction or vascular death during the study period. A total of 503 patients of mean age 63 (SD 12) years were included. A U-shaped relationship between urate quartiles and poor functional outcomes was demonstrated. More patients with low (<280 μM) and high (>410 μM) urate levels had poor functional outcomes (36% and 27% respectively), compared to those with urate levels between 340 and 410 μM (14%). No significant relationship was observed between urate and vascular outcomes. Depending on its level, serum urate may exhibit protective and deleterious effects on stroke outcomes. © 2009 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.atherosclerosis.2009.08.012
dc.sourceScopus
dc.subjectInfarction
dc.subjectPrognosis
dc.subjectStroke
dc.subjectUric acid
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentMEDICINE
dc.contributor.departmentCENTRE FOR MOLECULAR EPIDEMIOLOGY
dc.description.doi10.1016/j.atherosclerosis.2009.08.012
dc.description.sourcetitleAtherosclerosis
dc.description.volume209
dc.description.issue1
dc.description.page215-219
dc.description.codenATHSB
dc.identifier.isiut000275101500037
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