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Title: Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study
Authors: Seet, R.C.S. 
Kasiman, K. 
Gruber, J. 
Tang, S.-Y. 
Halliwell, B. 
Wong, M.-C.
Chang, H.-M.
Chan, Y.-H.
Chen, C.P.
Keywords: Infarction
Uric acid
Issue Date: 2010
Citation: Seet, R.C.S., Kasiman, K., Gruber, J., Tang, S.-Y., Halliwell, B., Wong, M.-C., Chang, H.-M., Chan, Y.-H., Chen, C.P. (2010). Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study. Atherosclerosis 209 (1) : 215-219. ScholarBank@NUS Repository.
Abstract: Contrasting observations have been made between serum urate and ischemic stroke outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is associated with stroke outcomes, a prospective follow-up study was performed in a cohort of Asian patients with ischemic stroke. Patients diagnosed with transient ischemic attack, first or recurrent ischemic stroke were included in this study. Serum urate, measured using high-performance liquid chromatography, was correlated with 12-month functional and vascular stroke outcomes. Poor functional outcome was defined as a modified Rankin scale exceeding 2 and vascular outcome was defined as a composite of recurrent stroke, myocardial infarction or vascular death during the study period. A total of 503 patients of mean age 63 (SD 12) years were included. A U-shaped relationship between urate quartiles and poor functional outcomes was demonstrated. More patients with low (<280 μM) and high (>410 μM) urate levels had poor functional outcomes (36% and 27% respectively), compared to those with urate levels between 340 and 410 μM (14%). No significant relationship was observed between urate and vascular outcomes. Depending on its level, serum urate may exhibit protective and deleterious effects on stroke outcomes. © 2009 Elsevier Ireland Ltd. All rights reserved.
Source Title: Atherosclerosis
ISSN: 00219150
DOI: 10.1016/j.atherosclerosis.2009.08.012
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