Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2008.12.016
DC FieldValue
dc.titleElevation of oxidative-damage biomarkers during aging in F2 hybrid mice: Protection by chronic oral intake of resveratrol
dc.contributor.authorWong, Y.T.
dc.contributor.authorRuan, R.
dc.contributor.authorTay, F.E.H.
dc.contributor.authorGruber, J.
dc.contributor.authorJenner, A.M.
dc.contributor.authorNg, M.P.-E.
dc.date.accessioned2011-11-29T06:09:58Z
dc.date.available2011-11-29T06:09:58Z
dc.date.issued2009
dc.identifier.citationWong, Y.T., Ruan, R., Tay, F.E.H., Gruber, J., Jenner, A.M., Ng, M.P.-E. (2009). Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: Protection by chronic oral intake of resveratrol. Free Radical Biology and Medicine 46 (6) : 799-809. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2008.12.016
dc.identifier.issn08915849
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28829
dc.description.abstractResveratrol (RSV), a naturally occurring phytoalexin that can be found in red wine, berries, and peanuts, has been shown to extend both mean and maximum life span in model organisms. RSV has also been reported to shift the physiology of middle-aged mice on a high-calorie diet toward that of mice on a standard diet. These beneficial effects of RSV have been suggested to resemble caloric restriction. Our study in F2 four-way cross-hybrid mice was the first to evaluate the effects of aging and long-term RSV treatment (14.09 ± 3.4 mg/L in drinking water for 6 or 12 months) on biomarkers of oxidative damage to DNA, 8-hydroxy-2′-deoxyguanosine (8OHdG); lipid, 8-iso-prostaglandin2α (8-iso-PGF2α); and protein, protein carbonyl content (PCC). There was a significant age-dependent accumulation of oxidative damage to DNA, lipid, and protein as well as a clear increase in urine 8-iso-PGF2α levels in the majority of mouse tissues. Rates of age-dependent increases in damage biomarkers varied between tissues. Chronic RSV treatment elevated total RSV plasma levels and reduced the observed age-dependent accumulation of (1) 8OHdG in liver and heart, (2) 8-iso-PGF2α in heart and urine, and (3) PCC in liver and kidney. However, a 12-month RSV intake resulted in significant elevation of 8-iso-PGF2α and PCC in kidney. Our studies demonstrate that RSV treatment consistently attenuated oxidative damage in tissues where age-related oxidative damage accumulation was prominent, but also suggested that chronic RSV treatment may induce nephrotoxicity. © 2008.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.freeradbiomed.2008.12.016
dc.sourceScopus
dc.subject8-Hydroxy-2′-deoxyguanosine
dc.subjectAging
dc.subjectFree radicals
dc.subjectHybrid mice
dc.subjectIsoprostane
dc.subjectOxidative damage
dc.subjectProtein carbonyl
dc.subjectResveratrol
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentOTOLARYNGOLOGY
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1016/j.freeradbiomed.2008.12.016
dc.description.sourcetitleFree Radical Biology and Medicine
dc.description.volume46
dc.description.issue6
dc.description.page799-809
dc.description.codenFRBME
dc.identifier.isiut000264061400012
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